PAIN MECHANISMS: FROM MOLECULES TO TREATMENT
University of Minnesota, Twin Cities Campus, June 3-7, 2019
A course co-directed by Karolinska Institutet and University of Minnesota
MONDAY, June 3 – Basic Concepts (Location: 3-120 MCB)
08:00 Registration and Breakfast (Provided)
08:30 Welcome! Introductory remarks (G. Wilcox & R. Elde)
09:15 Nociceptors, nociception and pain (C. Honda)
10:00 Coffee Break
10:30 Dorsal horn structure and function (C. Honda)
11:15 Molecules involved in the transduction of pain and itch (A. Klein)
12:00 Lunch
13:00 Ascending nociceptive pathways (C. Honda)
13:45 Descending inhibition and facilitation (M. Wessendorf)
14:30 Coffee Break
15:00 Peripheral and central sensitization (V. Palada)
15:45 Neuroimmune interactions in chronic pain (C. Svensson)
16:30 Role of glial activation in pain (C. Svensson)
17:15 Adjourn
TUESDAY, June 4 (Location: 3-120 MCB)
Trigeminal System Symposium
08:00 Coffee
08:30 Trigeminal pain mechanisms (D. Bereiter)
09:15 Trigeminal Neuroanatomy Imaged with Ultra-High Field MRI (DTI approach) (K. Mulford)
09:45 Understanding Brain Mechanisms in OFP (fMRI and connectivity approach) (E. Moana)
10:15 Coffee Break
10:30 Investigating muscle pain mechanisms in painful TMD (clinical neuroscience approach) (M. Ernberg)
11:15 Pain in relation to Root Canal Treatment (epidemiological approach) (D. Nixdorf)
12:00 Interprofessional Session with Andrew Grande, Jeannine Conway and Don Nixdorf
12:30 Lunch
Assessment of pain and nociception
13:30 Pain Classification: nociceptive, neuropathic, nociplastic (E. Kosek)
14:15 Overview of clinical pain testing (J. Persson)
15:00 Coffee Break
15:15 Managing pain in non-verbal patients and patients with developmental disorders (F. Symons, C. Barney)
16:00 Utility of QST and its Evolving Role in Research and Clinical Practice (M. Backonja)
17:00 Adjourn
WEDNESDAY, June 5 – Pharmacology and Treatment of Pain (Location: Mayo Auditorium)
08:00 Coffee
08:30 Sex Differences of Pain (M. Ernberg)
09:15 Proteomics of Pain (K. Kultima)
10:00 Coffee Break
10:15 Mechanisms of action of established analgesic drugs (C. Fairbanks)
10:45 Peripheral and central targets for new analgesic drugs (G. Wilcox)
11:15 Sensory Assessment in Animals (L. Vulchanova/C. Peterson)
12:00 Lunch
13:00 Pre-clinical pain testing: NIH Consensus Conference (C. Peterson)
13:45 Considerations for Early Phase Analgesic Trial Design (M. Backonja)
14:30 Coffee Break
14:45 Exercise therapy in chronic muscle pain (mechanisms/effects) (M. Ernberg)
15:30 Complementary and alternative therapies for chronic pain (T. Falkenberg)
16:15 Integrative health care of pain: social and genomic sustainability (T. Falkenberg)
17:00 Adjourn
THURSDAY, June 6 – Chronic Pain Syndromes (Location: 3-120 MCB)
08:00 Coffee
08:30 Clinical Pain Management Introduction (M. Belgrade)
09:15 Visceral Pain Including IBS (J. Persson)
10:00 Coffee Break
10:15 Mechanisms of Fibromyalgia (A. Larson)
11:00 Musculoskeletal Pain and Fibromyalgia (E. Kosek)
11:45 Headache (K. Nixdorf)
12:30 Lunch
13:30 KEYNOTE (Location: Mayo Memorial Building Auditorium)
Role of Opioids in Pain Management: Clinical and Regulatory Perspectives
(Greg Terman, M.D., Ph.D., Dept of Anesthesiology University of Washington
Past President, American Pain Society)
14:30 Pharmacy and Pain Management (V. Ghafoor)
15:15 Coffee Break
15:30 Panel Discussion on Opioid Epidemic (Ghafoor, Moderator)
16:15 Panel Discussion on New Pain Management Strategies (Belgrade, Moderator)
17:00 Adjourn
FRIDAY, 7 June (Location: Mayo Auditorium)
08:00 Coffee
08:15 Course Exam
Mississippi River Basic Science Pain Research
09:15 Session I: Opening Remarks (L. Vulchanova)
09:30 Lucy Vulchanova
09:45 Jan Persson
10:00 Alice Larson
10:15 Eva Kosek
10:30 Alonso Guedes
10:45 Malin Ernberg
11:00 Coffee Break
Session II
11:15 Sergey Khasabov
11:30 Vinko Palada
11:45 Cristina Peterson
12:00 Kim Kultima
12:15 Amanda Klein
12:30 Ying Wang
12:45 Lunch Provided and Poster Session (Location: Lobby of Mayo Auditorium)
Session III
14:00 Iryna Khasabova
14:15 Torkel Falkenberg
14:30 Dave Bereiter
14:45 Kelsey Pflepsen
15:00 Rebecca Speltz
15:15 Don Simone
15:30 Simone Demo
15:45 Closing Remarks